Women are 2 to 9 times more likely to experience an anterior cruciate ligament (ACL) injury than men. Various hormones including relaxin, progesterone, and estrogen influence ACL strength. Oral contraceptives (OCs) alter these hormone levels; however, studies have yet to comprehensively compare different OCs’ effects on the ACL.
In conclusion, OC formulations with higher progestin-to-estrogen ratios may be more protective for the ACL than formulations with lower ratios.
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