Primeadine
Spermidine – The Powerful AntiAging compound you’ve never heard of but that is about to take
the world by storm. In this episode I sit down with Leslie Kenny the CEO and Founder of
OxFord Healthspan – a company founded for the purpose of bringing powerful healthy/anti
aging compounds to market. Today we deep dive into their first entry which is rooted in
ancient knowledge and yet relatively new to the modern world. Consider that this compound
hits at least 5 of the 9 hallmarks of aging….even better, new research seems to point to its
ability to improve immune response in elderly adults by helping certain areas of the immune
system to reboot and rejuvenate!! Oxford Span is committed to making this
supplement available to as many people as possible – for the month of December you can
benefit from introductory pricing PLUS an additional 15% discount (BIONAT15 promo code). If
you are this after December 2020 the discount code will still work!!
Note that this supplement will produce most noticeable results in the 50+ crowd who are
already seeing a decline in endogenous spermidine production and is not appropriate for
people with celiac disease or severe wheat allergies – we talk about all this and more in the
episode….enjoy!!
6:08
Leslie’s story – from autoimmune disease & infertility to how she first came across spermidine
7:22
The link between ancient Japanese scrolls on longevity and sexual intimacy and spermidine
11:05
Compounds that target the 9 hallmarks of aging and the 5 specifically targeted by Spermidine
13:30
Dietary sources and the reason why supplement companies are having to extract spermidine
from wheat instead of Natto
15:30
Natto – possibly the best and most economical source of spermidine
17:33
Who should NOT use the current Spermidine supplements (including Primeadine) and why
18:02
Amount of gluten per serving vs a slice of
19:54
Why the 50+ crowd is likely to experience the best visible results from Primeadine
20:55
Endogenous and exogenous sources of spermidine
22:57
The physical signs that your spermidine production is declining
28:20
Short, medium and long term benefits
36:05
Maximum dose as determined by regulatory bodies
38:49
Getting back to the ancient Daoist Scrolls – the aging male’s advantage over women
45:29
Best time of day to take Primeadine
50:27
DO NOT mix with hot foods or beverages
52:25
Introductory pricing in place until December 31, 2020
15% discount code in place for December and the new year: BIONAT15
Website:
Primeadine.com or OxfordHealthSpan.com
Just a few of the growing list of studies assessing Spermidine’s possible benefits for human
and longevity
Studies/References
Effect on Hormones, Fertility in men and women
The regulatory effect of biogenic polyamines spermine and spermidine in men and women. Open
Journal of Endocrine and Metabolic Diseases, 9(03), 35
Spermidine Intake and Longevity in humans
Higher spermidine intake is linked to lower mortality: a prospective population-based study. The
American journal of clinical nutrition, 108(2), 371-380
The autophagy enhancer spermidine reverses arterial aging in aged mice. Mechanisms of ageing
and development, 134(7-8), 314-320.
Okamoto, A., Sugi, E., Koizumi, Y., Yanagida, F., & Udaka, S. (1997). Polyamine content of ordinary
foodstuffs and various fermented foods. Bioscience, biotechnology, and biochemistry, 61(9), 1582-
1584
Ramot, Y., Tiede, S., Bíró, T., Bakar, M. H. A., Sugawara, K., Philpott, M. P., ... & Paus, R. (2011).
Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell
functions. PLoS One, 6(7), e22564
Rinaldi, F., Marzani, B., Pinto, D., & Ramot, Y. (2017). A spermidine-based nutritional supplement
prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-
blind study. Dermatology Practical & Conceptual, 7(4), 17.
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A. (2020).
Spermidine intake is associated with cortical thickness and hippocampal volume in older adults.
NeuroImage, 221, 117132
Dietary polyamine intake and colorectal cancer risk in postmenopausal women. The American
journal of clinical nutrition, 102(2), 411-419
And finally an article on new findings of the effects of Spermidine on immune function is elderly
humans:
https://www.longevity.technology/autophagy-in-t-cells-maintained-by-
spermidine/?utm_source=ZohoCampaigns
Please note that this content is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Always seek the advice of your physician or care provider with any questions or concerns you may have regarding a medical condition before you make any changes.
