After a disruptive year in 2020, there are new challenges in 2021, but also immense opportunities in numerous fields. In a deep and wide-ranging conversation, Mark Maunder and Kathy Zant discuss artificial intelligence, whether or not we're living in simulation, cryptocurrencies and the opportunities of blockchain technology, open source communities and publishing, avoiding scams and FOMO, as well as what fields are most promising for the next 10 years.