This podcast presents an approach to Childhood Nephrotic Syndrome. Listeners will learn about the clinical presentation and diagnostic criteria, list key initial investigations to refine the differential diagnosis in children presenting with edema and/or proteinuria, and review an approach for the management of patients with childhood nephrotic syndrome. Listeners will also recall common complications and delineate outcomes. This podcast was developed by Summer Hudson, a second year medical student at the University of Alberta, in collaboration with Dr. Melanie Lewis, a general pediatrician, and Dr. Catherine Morgan, a pediatric nephrologist, who both work at the Stollery Children’s Hospital in Edmonton, Alberta, Canada.