This podcast is part one of two podcasts that explore cystic fibrosis (CF) in children. This episode focuses on the early presentations of CF and reviews the pathophysiology and etiology of CF in newborns, the presentation and diagnosis of CF in newborns as well as describes the Newborn CF screening all through a case-based approach. This podcast was developed by Dr. Rose Sun, a second-year Paediatrics resident at the Hospital for Sick Children in Toronto, with the support of Dr. Tamizan Kherani, a pediatric respirologist at the Stollery Children’s Hospital in Edmonton, and Dr. Mariam Ayed, a neonatologist and clinical epidemiologist at Farwaniya Hospital and Kuwait University.