Today's episode looks at the ways in which the body balances out excess food intake to try and maintain homeostasis. The study reviewed today particularly looks at the role of the hormone adiponectin in this context. The applications half of the episode challenges calories in vs. calories out dogma and provides rationale for individualizing nutrition recommendations. John always reviews the full text of every article, but to see the abstract of the study discussed, click here: http://www.ncbi.nlm.nih.gov/pubmed/24023698