#249 Brice Challamel: How Moderna is Using AI to Disrupt Modern Healthcare

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In this episode of Eye on AI, Craig Smith sits down with Brice Challamel, Head of AI Products and Innovation at Moderna, to explore how one of the world’s leading biotech companies is embedding artificial intelligence across every layer of its business—from drug discovery to regulatory approval.

Brice breaks down how Moderna treats AI not just as a tool, but as a utility—much like electricity or the internet—designed to empower every employee and drive innovation at scale. With over 1,800 GPTs in production and thousands of AI solutions running on internal platforms like Compute and MChat, Moderna is redefining what it means to be an AI-native company.

Key topics covered in this episode:

How Moderna operationalizes AI at scale

GenAI as the new interface for machine learning

AI’s role in speeding up drug approvals and clinical trials

The future of personalized cancer treatment (INT)

Moderna’s platform mindset: AI + mRNA = next-gen medicine

Collaborating with the FDA using AI-powered systems

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(00:00) Preview 

(02:49) Brice Challamel’s Background and Role at Moderna

(05:51) Why AI Is Treated as a Utility at Moderna

(09:01) Moderna's AI Infrastructure

(11:53) GenAI vs Traditional ML

(14:59) Combining mRNA and AI as Dual Platforms

(18:15) AI’s Impact on Regulatory & Clinical Acceleration

(23:46) The Five Core Applications of AI at Moderna

(26:33) How Teams Identify AI Use Cases Across the Business

(29:01) Collaborating with the FDA Using AI Tools

(33:55) How Moderna Is Personalizing Cancer Treatments

(36:59) The Role of GenAI in Medical Care

(40:10) Producing Personalized mRNA Medicines

(42:33) Why Moderna Doesn’t Sell AI Tools

(45:30) The Future: AI and Democratized Biotech