#255 Eric Topol: Why AI is the Most Powerful Tool in Healthcare Now

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What if AI could predict exactly when you'd get sick—and help you prevent it?

In this episode of Eye on AI, Dr. Eric Topol, world-renowned cardiologist, author, and AI health pioneer, joins us to unveil the future of preventive medicine. We dive deep into the themes of his new book Super Agers, which lays out a groundbreaking blueprint for extending healthspan—not just lifespan—through the power of multimodal AI and deep biological data.

Dr. Topol explains how AI models can now analyze a full-stack of human data—genomics, proteomics, metabolomics, microbiome, and more—to forecast age-related diseases like cancer, Alzheimer’s, and heart disease decades before symptoms appear. This isn’t science fiction. It’s here now.

If you're interested in the intersection of AI, longevity, and the future of medicine, this is a must-listen.

Where AI Works tackles the big questions shaping AI’s role in business today, cutting through the hype to deliver actionable insights for leaders. Brought to you by the Wharton School, in collaboration with Accenture, this podcast combines cutting-edge research with real-world case studies to uncover how top companies are using AI to upskill workforces, enhance customer experiences, boost productivity, and streamline operations. 

Check it out:  https://link.cohostpodcasting.com/f5e223b4-da0c-4fc8-bbf3-5f24c15f8fd2?d=sxo9xhJN2 

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(00:00) The Power of Precision Medical Forecasting

(01:53) Eric Topol’s Journey into Digital & AI Medicine

(03:27) Using AI to Prevent Aging-Related Diseases

(05:25) The Challenge of Health Data Privacy & Ownership

(09:05) Genetic Risk to Deep Data Insights

(11:20) Personalized Prevention Through Lifestyle & Biomarkers

(13:59) Why Anti-Aging Drugs Are Still Years Away

(16:18) What are Organ Clocks

(19:34) The Longevity Industry’s Flawed Use of AI

(21:59) Top AI Pioneers Endorse “Super Agers”

(24:21) Which Longevity Startups Are Getting It Right?

(26:27) Why Topol Refuses to Join Longevity Startups

(28:57) Topol’s Own Health Data & Lessons Learned

(30:25) How Accurate Is AI at Predicting Disease Timing?

(31:47) The Truth About Genetic Risk and Cancer Detection

(33:33) AI-Driven Cancer Detection: A Smarter Approach

(38:51) How Precision Medicine Has Evolved

(41:02) The Risky Reality of Anti-Aging Interventions

(44:39) Why Healthspan Matters More Than Lifespan